From the current research, the ultrafine pulverization technology of the ultrafine pulverizer is applied to the advantages of two aspects of the Chinese medicine (explained: the favorable situation that can overwrow the other party) is: 1. Obviously improve the dissolution rate of drug in vitro dissolution indicators and its extraction rate drugs and the particles of the drug are proportional to the particles of the drug, rather than being inversely proportional to the particle size. The ultrafine pulverizer utilizes air separation, heavy polishing, and shear, the ultrafine manner is used to achieve a dry material ultrafine pulverized apparatus.
It consists of a cylindrical crushed chamber, a polishing wheel, a polishing rail, a fan, a material collection system, and the like. The material enters the cylindrical pulverizing chamber by the feed opening, and is crushed by the polishing wheel that is circumferential movement along the grinding rail, and dissensibly. When the ultrafine pulverizer works, the material that needs to be pulverized from the feed homper side of the side of the machine cover, relying on the grinding roller apparatus suspended on the main chamber frame, rotating around the vertical axis, while itself rotates, due to rotation The action of centrifugation, the grinding roller is swinging, tightly pressed into the mill, and the shovel shovel is sent between the mill and the abrasive ring, and the purpose of pulverizing the material is achieved due to rolling rolling of the grinding roller.
Therefore, the finer the particle size of the drug, the larger the specific surface area, the more contributes to the dissolution of the drug active ingredient. At the same time, due to the broken wall of the medicinal material cells, all kinds of active ingredients in the cells are released, shorten the extraction time, improve the excess of Chinese medicine, especially the dissolution, diffusion of macromolecular components in the Chinese medicine, thereby achieving shortening the medicinal material extraction time and The purpose of improving the effective ingredient extraction rate in the medicinal material. 2.2 Improve the drug bioavailability, enhance the hyperbarcum material in the pharmaceutical effects in the drug effect, after the ultrafine pulverizer of the Chinese medicine ultrafine pulverizer, due to its small particle size uniform (jūn yún), the specific surface area increases, increased porosity, adsorption, solubility, solubility Increased, the affinity became large, the reaction rate increased, the drug can be dissolved in the gastrointestinal fluid, and the gastrointestinal mucosa is contacted, and it can be tightly adhered to the mucosa in the gastrointestinal wall, It increases in the gastrointestinal residence time, absorbs more sufficient, and the amount of absorption will increase, thereby greatly improving its bioavailability.
Tianma ordinary powder and ultrafine powder have the effect of anti-cyclopectic and ischemia-reperfusion injury nerve cell apoptosis, and this effect of ultrafine powder is more obvious. Adding antibacterial (Fungus) Experiments (Experiment) Research (Experiment) Antibacterial CapsuleFor use, it is found that the drug dose can reduce the mortality rate of stypes during 10 g / kg, and the capsules and tablets made of traditional pulverization methods have no effect. Indicates that there is a pharmacological role that has ordinary capsules with ultra-fine powder capsules in a certain dose.
Designed tolerance (Oxygen) Experiment (Experiment) Experiments to investigate the effects of Western ginseng (Caragin) pink to increase mice. When the ultrafine pulverizer works, the material that needs to be pulverized from the feed homper side of the side of the machine cover, relying on the grinding roller apparatus suspended on the main chamber frame, rotating around the vertical axis, while itself rotates, due to rotation The action of centrifugation, the grinding roller is swinging, tightly pressed into the mill, and the shovel shovel is sent between the mill and the abrasive ring, and the purpose of pulverizing the material is achieved due to rolling rolling of the grinding roller.
As a result, the ultrafine powder increased by 1 to 2 μm was increased by 79.64%, 5 to 7 μm, and the amount of the former active ingredient was increased, and the anecdoxic effect was obvious, indicating that the western ginseng powder is different. Its displays differ from the degree of drug activity. Through clinical observations: Terminal microfourd can effectively inhibit blood vessel intake injury in patients with cerebral infarction than its coarse powder, and platelet activation can effectively improve the clinical efficacy of patients with cerebral infarction.
The ultrafine powder and granules of the hot plate method were used to study the ultrafine powder and granules of the ant attachment, and the superfine powder was found to be 1/2 of the particulate agent, two The role is basically similar. By observing different doses of puerarial ultrafine powder on the coagulation time of mice, the dose of Pueraria ultrafine powder (0.6 g / kg) can significantly increase the coagulation time of mice. Holy super-fine powder high, low-dose group can significantly reduce high-fat model rat serum total cholesterol, triacylglyceride, low density (unit: g / cm3 or kg / m3) fat The level of protein cholesterol (P <0.01). Ultrafine pulverization helps to improve the efficacy of white-range, reduce the amount of pharmaceutics, which is conducive to the modernization of dosage form.