Cellular micronization and influence of absorption in vivo

　　Chinese medicine cell grade microclock is a crushing operation using a traditional Chinese medicine ultrafine pulverizer to break into the wall of plant medicinal material cells and is not based on fineness. The ultrafine pulverizer Zky series can be widely used in the ultrafine comminution demand for traditional Chinese medicine, western medicine, pesticide, biological, cosmetics, food, feed, chemical, chemical, ceramics. Especially for fibrotic, high toughness, such as Cordyceps, tea, Ganoderma lucidum, etc. is more perfect. The active ingredients of the cells were sufficiently exposed after the broken wall, and the release rate and release of the drug will increase significantly. After the drug particles were slightly pulverized by cell grade, only a very small amount of intact cells were observed under microscope. The mixed uniform mixed uniform (Jūn yún) degree (also known as homogenization) should be based on fineness, the finer the particle size, the higher the mixing uniformity. However, due to static electricity (a charge in a stationary state) and the absorption, the finer is finer, the more homogenization is difficult (Difficult). This is due to the general water content of traditional Chinese medicine is more than 6%, and some have a certain oily and volatile ingredient, which is a mixture of two polarities. In the process of microcltrametric micronization, it is uniformly mixed by high strength (Strength) shear force, and the effect of liquid phase mixing and emulsification can be achieved. The compound pulverization of Guiuxi Huang Pill was used as an example. The form exists. Ultrafine pulverizer is a fine powder and ultrafine powder pulverization equipment, which is mainly suitable for medium, low hardness, humidity of less than 6%, and a non-flammable and explosive non-metallic material of the Moh's hardness is below 9. For any fibrous, high toughness, high hardness, or materials having a certain water rate can be adapted. The material of the cell wall and other spore plants, which are higher than 95%. At the same time, it is suitable for dry and wet crushing. Wet, water, alcohol or other liquid can be added thereto. Due to the breaking of the cell wall during the pulverization, the cellular moisture and the oil have caused the surface of the fine particles to become a semi-humid state, and the particles and particles form a semi-stable (explained: stable stability; no change) particle group (or For microparticles), the size of the particle group is the pulverized particle size we detected by the conventional screening method. Each particle group contains the same proportion of Chinese medicine ingredients, and will be due to different drugsDifferences, such as HLB values, ductility, crushability, water (oil) rate, absorbent (oil), specific gravity, etc., and determine the physical structure of the particle group. This structure is called "solid emulsification". In fact, during the mixed pulverization process, due to the influence of intracellular moisture, the surface of the material will be semi-humid state, and the particles are more secure between the particles and the particles, which has a considerable stability (explanation: stable stability; no change) (the STABILITY OF). The oily and volatile ingredients are simultaneously adsorbed while mixing pulverization at some of the surfaces of some solids and semi-liquid components, and some of the propylene materials are easily processed with a hydrophilic component to achieve homogeneous purposes. If it is stirred in water, it does not produce segregation between oily and water-based ingredients. When the ultrafine pulverizer works, the material that needs to be pulverized from the feed homper side of the side of the machine cover, relying on the grinding roller apparatus suspended on the main chamber frame, rotating around the vertical axis, while itself rotates, due to rotation The action of centrifugation, the grinding roller is swinging, tightly pressed into the mill, and the shovel shovel is sent between the mill and the abrasive ring, and the purpose of pulverizing the material is achieved due to rolling rolling of the grinding roller. Since the cell grade micro-pulverization occurs while breaking the oil cells in the medicinal material, the compound Chinese medicine containing a volatile component produces a volatile reduction or an improved phenomenon due to different conditions. The oily and volatile ingredients of the homogeneous compound Chinese medicine can be dispersed in the stomach, which is uniform (jūn yún), which is uniformly absorbed with other water-soluble ingredients in the small intestine due to drug homogeneity. This absorption speed of unbroken wall medicinal materials in conventional pulverization will be large. The powder obtained by this method can be directly granulated without adding any excipients. The fibers in the medicinal materials have reached ultrafine, which has the effect of having a pharmaceutical excipient medium, so it is easy to form. At the same time, the fibers have a certain amount of water absorption (inflate), and the expansion of ultrafine fibers is much larger, and the disintegration speed is faster in the stomach. After the drug disintegration, the fineness is extremely fine and homogeneous, after the proportion of the original ingredient enters the small intestine, while the components are absorbed by the human body while adsorbing the intestinal wall. The case where it is crushed and mixed with conventional ways. Due to the large pulverization particle size, the mixed uniformity is low, and the pharmaceutical composition of different traits is due to its fineness, the cell swelling speed, from the cell wall.The migration speed, HLB value and the difference in adsorption of intestinal wall are absorbed by the human body at different times, and the absorption value is also different, thereby affecting the efficacy of compound drugs.